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Breakthrough: Indian Scientists Re-Design Anti-Cancer Drug To Make It More Effective

siliconreview Breakthrough: Indian Scientists Re-Design Anti-Cancer Drug To Make It More Effective

Developing an anti-cancer drug is not a cup of tea and the drugs are generally very toxic and lead to serious health issues among the patients.

Few Indian researchers have re-designed one of those toxic drugs to obtain new chemicals and could potentially be anti-bacterial and anti-cancer drugs. The team synthesized a compound called Sunitinib (a drug used to treat Kidney cancers). Among them, anyone drug would be effective than Sunitinib itself.

Sunitinib, like any other drugs, has serious side effects. Different scientists around the world are working on it to reduce the toxic effects and increase its potency.

Sunitinib’s structure consists of-

Indole-2 ring, a pyrrole structure,and a diethylaminoethyl substituted carboxamide group.

The scientists developed compounds and tested them on different types of human cancer cells. The cells included monocyte, breast, prostate,and cervical.  Additionally, the second part of the test was conducted by testing new compounds on a few types of bacteria. The bacteria were Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis,and Staphylococcus aureus.

Seven compounds from the test were effective against both cancer cells and bacteria. Later on, the compounds were tested to check if its effectiveness could be improved.

9g, one of the compounds from the test was the most effective as it shown resistance against cancer cells and bacterial agents. Other compounds were showing anti-bacterial characteristics and anti-proliferation activity.

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